Integrated multi-modal transport and transit systems that optimize the comparative advantages of each mode of transport are crucial in order to achieve sustainable transport of passengers and freight within and between countries. Road, rail, maritime, ferry and air transport, as well as non-motorized transport such as walking and cycling, need to be taken into account and emphasis should be placed on low-carbon-based energy modes of transport and an increased reliance on public transport systems. Sustainable multimodal transport and transit systems can provide an array of options for passenger and freight transport and successfully connect citizens and countries while supporting economic growth, social development and global trade. Transporting goods across national borders and over “the last mile” to their final destination in a safe, efficient and effective way is an ongoing challenge. Solutions will require collaboration between governments and across modes, and regional initiatives will be important to harmonize legal and policy frameworks.